Water → N-[3-fluoro-4-[2-[4-(3-hydroxypyrrolidine-1-carbonyl)phenyl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-2-(4-fluorophenyl)-3-oxopyridazine-4-carboxamide

HRID 1232529Notes

Reaction equation

HRID 1232529 reaction equation
[CH3:44][CH2:45][N:46]=[C:47]=[N:48][CH2:49][CH2:50][CH2:51][N:52]([CH3:53])[CH3:54].[CH:61]([N:62]([CH2:63][CH3:64])[CH:65]([CH3:66])[CH3:67])([CH3:68])[CH3:69].[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:14]2[cH:15][cH:16][c:17]([C:18](=[O:19])[OH:20])[cH:21][cH:22]2)[s:13]3)[cH:23][cH:24][c:25]([NH:27][C:28](=[O:29])[c:30]2[cH:31][cH:32][n:33][n:34](-[c:37]3[cH:38][cH:39][c:40]([F:43])[cH:41][cH:42]3)[c:35]2=[O:36])[cH:26]1.[NH:55]1[CH2:56][CH:57]([OH:60])[CH2:58][CH2:59]1.[O:71]=[CH:72][N:73]([CH3:74])[CH3:75].[OH2:70]>>[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:14]2[cH:15][cH:16][c:17]([C:18](=[O:20])[N:55]4[CH2:56][CH:57]([OH:60])[CH2:58][CH2:59]4)[cH:21][cH:22]2)[s:13]3)[cH:23][cH:24][c:25]([NH:27][C:28](=[O:29])[c:30]2[cH:31][cH:32][n:33][n:34](-[c:37]3[cH:38][cH:39][c:40]([F:43])[cH:41][cH:42]3)[c:35]2=[O:36])[cH:26]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81531DiisopropylethylamineHCID 982104-HydroxypyrrolidineHCID 673452974-(7-(2-Fluoro-4-(1-(4-fluorophenyl)-6-oxo-1,6-dihydropyridazine-5-carboxamido)phenoxy)thieno[3,2-b]pyridin-2-yl)benzoic acid

Product 1

HCID 67347248N-[3-fluoro-4-[2-[4-(3-hydroxypyrrolidine-1-carbonyl)phenyl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-2-(4-fluorophenyl)-3-oxopyridazine-4-carboxamide

Sources & evidence

ORD record
ord-6b9f42cc41ac4f8aace5da546c90b0bb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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