Dimethyl Sulfoxide → Tert-butyl 4-(5-methyl-7-oxo-5,6-dihydrocyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate

HRID 1233099Notes

Reaction equation

HRID 1233099 reaction equation
[CH3:1][S:2]([CH3:3])=[O:4].[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:45][CH2:46][O:47][C:48]([CH3:49])=[O:50].[Cl:42][CH2:43][Cl:44].[Cl:5][C:6]([C:7]([Cl:8])=[O:9])=[O:10].[OH2:51].[OH:11][CH:12]1[CH2:13][CH:14]([CH3:34])[c:15]2[c:16]1[n:17][cH:18][n:19][c:20]2[N:21]1[CH2:22][CH2:23][N:24]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:26]1>>[O:11]=[C:12]1[CH2:13][CH:14]([CH3:34])[c:15]2[c:16]1[n:17][cH:18][n:19][c:20]2[N:21]1[CH2:22][CH2:23][N:24]([C:27](=[O:28])[O:29][C:30]([CH3:31])([CH3:32])[CH3:33])[CH2:25][CH2:26]1

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 65578Oxalyl chlorideHCID 66618169tert-butyl 4-[(5R,7R)-7-hydroxy-5-methyl-5H,6H,7H-cyclopenta[d]pyrimidin-4-yl]piperazine-1-carboxylate

Product 1

HCID 66618145Tert-butyl 4-(5-methyl-7-oxo-5,6-dihydrocyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-875d5e6a61c844448c7110fc527d70cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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