(1,1'-Biphenyl)-2-ol → Ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate

HRID 1237061Notes

Reaction equation

HRID 1237061 reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[C:25]([CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])([O:32][CH2:33][CH3:34])=[O:35].[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[Cs+:5].[Cs+:6].[Cu:54][I:55].[F:7][c:8]1[c:9]([C:15](=[O:16])[N:17]2[CH2:18][CH2:19][CH:20]([O:23][CH3:24])[CH2:21][CH2:22]2)[cH:10][c:11]([I:14])[cH:12][cH:13]1.[c:36]1(-[c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]2[OH:43])[cH:44][cH:45][cH:46][cH:47][cH:48]1>>[F:7][c:8]1[c:9]([C:15](=[O:16])[N:17]2[CH2:18][CH2:19][CH:20]([O:23][CH3:24])[CH2:21][CH2:22]2)[cH:10][c:11]([CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:12][cH:13]1

Participants

8

Reactant 7

HCID 7017(1,1'-Biphenyl)-2-olHCID 7761Diethyl MalonateHCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 57791814(2-Fluoro-5-iodophenyl)(4-methoxypiperidin-1-yl)methanone

Product 1

HCID 57791780Ethyl 2-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl)acetate

Sources & evidence

ORD record
ord-640786a090e649cd8ddd1bb621509db6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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