Ammonium → 1-Benzyl-4-(2,5-difluorobenzyl)piperidin-4-ol
Reaction equation
[Br:3][CH2:4][c:5]1[c:6]([F:12])[cH:7][cH:8][c:9]([F:11])[cH:10]1.[CH2:13]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[N:20]1[CH2:21][CH2:22][C:23](=[O:26])[CH2:24][CH2:25]1.[CH3:29][CH2:30][O:31][CH2:32][CH3:33].[Cl-:27].[I:2].[Mg:1].[NH4+:28]>>[CH2:4]([c:5]1[c:6]([F:12])[cH:7][cH:8][c:9]([F:11])[cH:10]1)[C:23]1([OH:26])[CH2:22][CH2:21][N:20]([CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[CH2:25][CH2:24]1Participants
8
Sources & evidence
- ORD record
- ord-55aad8fa272d4e29b5790f2cc8039bb1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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