Acetate → Ethyl 3-(2-methoxypyrimidin-5-yl)acrylate

HRID 124140Notes

Reaction equation

HRID 124140 reaction equation
[C:10]([CH:11]=[CH2:12])(=[O:13])[O:14][CH2:15][CH3:16].[CH3:1][O:2][c:3]1[n:4][cH:5][c:6]([Br:9])[cH:7][n:8]1.[CH3:39][CH2:40][N:41]([CH2:42][CH3:43])[CH2:44][CH3:45].[O-:48][C:49]([CH3:50])=[O:51].[O-:52][C:53]([CH3:54])=[O:55].[OH2:46].[Pd+2:47].[c:17]1([CH3:18])[cH:19][cH:20][cH:21][cH:22][c:23]1[P:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][c:30]1[CH3:31])[c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1[CH3:38]>>[CH3:1][O:2][c:3]1[n:4][cH:5][c:6]([CH:12]=[CH:11][C:10](=[O:13])[O:14][CH2:15][CH3:16])[cH:7][n:8]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 962WaterHCID 8471TriethylamineHCID 8821Ethyl AcrylateHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 139657Pyrimidine, 5-bromo-2-methoxy-

Product 1

HCID 53940995Ethyl 3-(2-methoxypyrimidin-5-yl)acrylate

Sources & evidence

ORD record
ord-dd3cceca15f1449bb436d94cc526949e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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