反应详情

To L-homoserine (2 g) were added sodium hydrogen carbonate (3.7 g) and water (30 ml), and the mixture was stirred at room temperature for 1 hr. To the reaction mixture were further added benzyl chloroformate (3.9 ml) and ether (10 ml), and the mixture was stirred at room temperature for 18 hrs. The reaction mixture was diluted with ethyl acetate and washed with 1N hydrochloric acid. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated. The obtained crude product was purified by silica gel chromatography (ethyl acetate-hexane) to give the title compound (2.5 g).

1. stirringthe mixture was stirred at room temperature for 18 hrs
2. washwashed with 1N hydrochloric acid
3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
4. customthe solvent was evaporated
5. customThe obtained crude product
6. customwas purified by silica gel chromatography (ethyl acetate-hexane)