Cyanuric chloride → HCID 11300612, compound

HRID 1242622Notes

Reaction equation

HRID 1242622 reaction equation
[N:1]1[C:8]([Cl:9])=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].[CH3:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH2:17])=[CH:14][CH:13]=1>C1COCC1>[Cl:9][C:8]1[N:1]=[C:2]([Cl:3])[N:4]=[C:5]([NH:17][CH2:16][C:15]2[CH:18]=[CH:19][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)[N:7]=1

Participants

4

Reactant 2

HCID 7954Cyanuric chlorideHCID 754524-Methoxybenzylamine

Product 1

HCID 11300612HCID 11300612, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
0 °C

Procedure

To a solution of cyanuric chloride (1.5 g, 8.13 mmol) in THF (50 mL) Diisopropyethylamine (1.56 mL, 8.94 mmol) was added. The solution was placed in an ice-water bath (0° C.). Using a syringe, 4-methoxy-benzyl amine (1.16 mL, 8.94 mmol) dissolved in THF (150 mL) was slowly dripped into the reaction mixture. The reaction stirred at 0° C. for 3 hours. The crude compound was purified by column chromatography initially eluting with EA:Hexane (1:6). Compound was obtained as a white solid.

Workup

  1. customThe solution was placed in an ice-water bath
  2. custom(0° C.)
  3. customThe crude compound was purified by column chromatography
  4. washinitially eluting with EA:Hexane (1:6)
  5. customCompound was obtained as a white solid

Sources & evidence

ORD record
ord-1fa8c865e9944c979ef4ce116525752b
Source dataset
uspto-grants-2006_10
Patent number
US07115737B2

Reaction notes

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