反应详情

温度

-20 °C

An initial charge of 31.1 g (0.22 mol) of 2,2,6,6-tetramethylpiperidine in 350 ml of tetrahydrofuran is cooled down to −20° C. 135 ml of 1.6 M butyllithium in hexane (0.22 mol) are added dropwise at this temperature. The mixture is cooled down to -18° C. and 47.2 g (0.2 mol) of 1-fluoro-3-iodo-5-methylbenzene are added dropwise at this temperature. The reaction mixture is stirred for another hour at −80° C. and then treated with 52.5 g (0.2 mol) of 3-(4′-propylbicyclohexyl-4-yl)propenal. The mixture is allowed to warm to 0° C., hydrolyzed with water and diluted hydrochloric acid and then subjected to conventional work-up.

1. temperatureThe mixture is cooled down to -18° C.