反应详情

4-(3,4,5,6-Tetramethoxy-2-methylbenzyl)-2-(3-pyridyl)benzoic acid (60 mg, 0.1415 mmol), 4-dimethylaminopyridine (8.6 mg, 0.0704 mmol) and piperidine (24 mg, 0.2823 mmol) were dissolved in methylene chloride (5 ml), WSC-HCl (81 mg, 0.4225 mmol) was added thereto and the mixture was stirred at room temperature for 16 hours. The reaction solution was washed with water and dried and the solvent was evaporated therefrom. The residue was purified by preparative thin layer chromatography (methylene chloride:methanol=95:5) to give the title compound (62 mg, 0.1265 mmol, 89%).

1. washThe reaction solution was washed with water
2. customdried
3. customthe solvent was evaporated
4. customThe residue was purified by preparative thin layer chromatography (methylene chloride:methanol=95:5)