反应详情

A solution of 2.0 g (13.8 mmol) of cyclobutanedicarboxylic acid in 20 mL of DMF at 0° C. was treated with 7.7 mL (55.5 mmol) of triethylamine and 5.0 mL (41.6 mmol) of benzyl bromide. The reaction was warmed to rt and stirred overnight. The reaction was partitioned between H2O and CH2Cl2. The residue was purified with a 40M Biotage column using 1:1 v/v of hexanes/EtOAc as the eluant to afford the title compound: 1H-NMR (500 MHz) δ 1.95–2.03 (m, 2H), 2.55–2.58 (m, 4H), 5.14 (s, 4H), 7.24–7.37 (m, 10H).

1. customThe reaction was partitioned between H2O and CH2Cl2
2. customThe residue was purified with a 40M Biotage column