反应详情

The trityl ether of Section B (13.5 g, 0.027 mol) was added dropwise to an ice-cooled suspension of sodium hydride (80%, 1.6 g, 0.054 mol) in 150 mL of tetrahydrofuran under nitrogen. After stirring for 2 hours at room temperature, heat was applied (55° C.). 1-Bromodecane (6 g, 0.027 mol) was added dropwise; heating was continued for 6 hours. After cooling for 3 hours, water was added slowly. Diethyl ether (2×100 mL) was added, and the solution washed with 15 percent sodium thiosulfite, water, and brine. After drying over sodium sulfate, the ether was removed, and the residue was chromatographed with a gradient of hexanes:ethyl acetate (100:0 to 20:1) to give 9 g (52%) of a clear liquid.

1. temperaturecooled
2. temperatureheat
3. custom(55° C.)
4. temperatureheating
5. waitwas continued for 6 hours
6. temperatureAfter cooling for 3 hours
7. washthe solution washed with 15 percent sodium thiosulfite, water, and brine
8. dry with materialAfter drying over sodium sulfate
9. customthe ether was removed
10. customthe residue was chromatographed with a gradient of hexanes:ethyl acetate (100:0 to 20:1)