Hydrochloric Acid → HCID 21907496, compound

HRID 1247464Notes

Reaction equation

HRID 1247464 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[C:6]([C:11]3[S:15][C:14]([C:16]([O:18]C)=[O:17])=[CH:13][CH:12]=3)[CH:7]=[CH:8][CH:9]=2)[CH2:4][NH:3]1.[Li+].[OH-].Cl>C1COCC1.CO.C(OCC)C>[O:1]=[C:2]1[C:10]2[C:5](=[C:6]([C:11]3[S:15][C:14]([C:16]([OH:18])=[O:17])=[CH:13][CH:12]=3)[CH:7]=[CH:8][CH:9]=2)[CH2:4][NH:3]1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 21907504HCID 21907504, compound

Product 1

HCID 21907496HCID 21907496, compoundYield 89.6%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

A suspension of Example 127A (0.34 g, 1.24 mmol) in THF (30 mL) and methanol (30 mL) was treated with 1N LiOH (10 mL), stirred at room temperature for 5 hours, then acidified with 1N HCl and diluted with diethyl ether. The resulting suspension was filtered and the filter cake was washed with water and dried to give 288 mg of the desired product. MS (ESI(−)) m/e 258 (M−H)−.

Workup

  1. filtrationThe resulting suspension was filtered
  2. washthe filter cake was washed with water
  3. customdried

Sources & evidence

ORD record
ord-b9af2ea89dbb4b86b6980087cae026dd
Source dataset
uspto-grants-2006_10
Patent number
US07129260B2

Reaction notes

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