Hydrochloric Acid → 5-chloro-N2-(2-fluoro-4-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Reaction equation
[CH:41]([OH:42])([CH3:43])[CH3:44].[Cl:20][c:21]1[n:22][cH:23][c:24]([Cl:34])[c:25]([NH:27][c:28]2[n:29][nH:30][c:31]([CH3:33])[cH:32]2)[n:26]1.[ClH:35].[F:1][c:2]1[c:3]([NH2:4])[cH:5][c:6]([C:16]([F:17])([F:18])[F:19])[c:7]([N:9]2[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]2)[cH:8]1.[Na+:40].[O-:36][C:37]([OH:38])=[O:39]>>[F:1][c:2]1[c:3]([NH:4][c:21]2[n:22][cH:23][c:24]([Cl:34])[c:25]([NH:27][c:28]3[n:29][nH:30][c:31]([CH3:33])[cH:32]3)[n:26]2)[cH:5][c:6]([C:16]([F:17])([F:18])[F:19])[c:7]([N:9]2[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]2)[cH:8]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-bf701928c5744f208b703adc1e346abc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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