反应详情

To a stirred mixture of 18 parts of 2-phenyl-4(3H)-quinazolinone and 225 parts of N,N-dimethylformamide are added portionwise at room temperature 3.2 parts of sodium hydride dispersion 60% (exothermic reaction: the temperature rises to 34° C.). After the addition is complete, the whole is stirred for 10 minutes whereafter 12.4 parts of 2-bromoethanol are added dropwise (slightly exothermic). Upon completion, stirring is continued first for one hour at room temperature, then for 2 hours at 80° C. and further overnight at room temperature. The reaction mixture is cooled, poured onto water and the solid product is sucked off. It is washed with water and 2,2'-oxybispropane and dried in vacuo at 60° C., yielding 15 parts of 3-(2-hydroxyethyl)-2-phenyl-4(3H)-quinazolinone.

1. customexothermic reaction
2. customrises to 34° C.
3. additionAfter the addition
4. additionare added dropwise (slightly exothermic)
5. waitfor 2 hours at 80° C.
6. customfurther overnight
7. customat room temperature
8. temperatureThe reaction mixture is cooled
9. additionpoured onto water
10. washIt is washed with water and 2,2'-oxybispropane
11. customdried in vacuo at 60° C.