Hydrochloric Acid → HCID 13458590, compound

HRID 1248261Notes

Reaction equation

HRID 1248261 reaction equation
[CH2:1]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:13][CH2:14][CH2:15][C:16](=[O:20])[CH2:17][CH2:18][CH3:19].[ClH:21].CCOCC>C(O)(C)C>[ClH:13].[ClH:21].[CH2:1]([N:7]1[CH2:8][CH2:9][N:10]([CH2:14][CH2:15][C:16](=[O:20])[CH2:17][CH2:18][CH3:19])[CH2:11][CH2:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 27365131-HexylpiperazineHCID 134585881-Chlorohexan-3-one

Product 1

HCID 13458590HCID 13458590, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 15.3 g (0.09 mole) of n-hexyl piperazine and 12.3 g (0.091 mole) of 1-chloro-3-hexanone was heated to 100° C. for 5 minutes, cooled and dissolved in isopropanol. Isopropanolic HCl was added until acidic. Ether was added and the salt was filtered off. The product was crystallized from acetonitrile to yield 16.5 g of product with a melting point of 225°-230° C.

Workup

  1. temperaturecooled
  2. filtrationthe salt was filtered off
  3. customThe product was crystallized from acetonitrile

Sources & evidence

ORD record
ord-e035aef679dd4842b25164072c059a59
Source dataset
uspto-grants-1985_06
Patent number
US04523014

Reaction notes

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