Hydrochloric Acid → HCID 20279260, compound

HRID 1248262Notes

Reaction equation

HRID 1248262 reaction equation
[CH2:1]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:13][CH2:14][CH2:15][C:16](=[O:19])[CH2:17][CH3:18].[ClH:20].[CH:21](O)(C)C>>[ClH:13].[ClH:20].[CH2:1]([N:7]1[CH2:8][CH2:9][N:10]([C:14]2[CH2:15][C:16](=[O:19])[CH:17]=[CH:18][CH:21]=2)[CH2:11][CH2:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3776Isopropanol2×HCID 965263-Pentanone, 1-chloro-HCID 27365131-Hexylpiperazine

Product 1

HCID 20279260HCID 20279260, compound

Procedure

A mixture of 8.5 g (0.05 mole) of a n-hexyl piperazine and 6.8 g (0.056 mole) of 1-chloro-3-pentanone was heated to 140° for 5 minutes. The reaction product was dissolved in isopropanol and acidified with a solution of HCl in isopropanol. The dihydrochloride salt was filtered and crystallized from acetonitrile to give 11.0 g of white solid with a melting point of 230°-233° C.

Workup

  1. temperaturewas heated to 140° for 5 minutes
  2. filtrationThe dihydrochloride salt was filtered
  3. customcrystallized from acetonitrile

Sources & evidence

ORD record
ord-5eff00bce6754f48b4597b6f535d9fde
Source dataset
uspto-grants-1985_06
Patent number
US04523014

Reaction notes

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