反应详情

A solution of 4.7 g (0.05 mole) of 4-aminopyridine in 300 ml of anhydrous tetrahydrofuran was treated with 9.4 g (0.05 mole) of 2,6-dichlorophenylisocyanate. The solution was heated at reflux for 24 hours, cooled, and concentrated in vacuo to a solid. Recrystallization from aqueous ethanol afforded the crystalline product, mp 217°-219° C.

1. temperatureThe solution was heated
2. temperatureat reflux for 24 hours
3. temperaturecooled
4. concentrationconcentrated in vacuo to a solid
5. customRecrystallization from aqueous ethanol
6. customafforded the crystalline product, mp 217°-219° C.