4-Methoxybenzenethiol → HCID 18327504, compound

HRID 1250189Notes

Reaction equation

HRID 1250189 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.[Cl:10][C:11]1[N:16]=[C:15](Cl)[CH:14]=[CH:13][N:12]=1.[H-].[Na+]>>[Cl:10][C:11]1[N:16]=[C:15]([S:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:14]=[CH:13][N:12]=1

Participants

4

Reactant 3

HCID 127654-MethoxybenzenethiolHCID 24758Sodium hydrideHCID 775312,4-Dichloropyrimidine

Product 1

HCID 18327504HCID 18327504, compound

Procedure

The 2-chloro4-(4-methoxyphenylsulphanyl)pyrimidine was prepared in a similar manner to the analogous starting material of Example 1, from 4-methoxybenzenethiol (1.90 g, 13.4 mmol), 2,4-dichloropyrimidine (2.0 g, 13.4 mmol) and sodium hydride [60% dispersion in oil] (590 mg, 14.8 mmol) as an off-white solid m.p. 69-70°.

Sources & evidence

ORD record
ord-7db01ccdb16e4af0b532497b6e4e7098
Source dataset
uspto-grants-2002_01
Patent number
US06337335B1

Reaction notes

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