Methylamine → HCID 9840386, compound

HRID 1250210Notes

Reaction equation

HRID 1250210 reaction equation
C(OC([N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([N:15]2[C:19]([C:20]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]([CH3:29])[CH:21]=3)=[CH:18][NH:17][C:16]2=[O:30])=[CH:7]1)=O)C.CN>C1COCC1>[NH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([N:15]2[C:19]([C:20]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[N:22]([CH3:29])[CH:21]=3)=[CH:18][NH:17][C:16]2=[O:30])=[CH:7]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 11058459HCID 11058459, compound

Product 1

HCID 9840386HCID 9840386, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The sub-title product of step c) (0.17 g, 0.44 mmol) was dissolved in THF (3 ml) and aqueous methyl amine (40%, 3 ml) and stirred for 30 minutes. The solvent was removed and the product precipitated from diethyl ether to give the title compound (0.14 g, 94%) as a slightly brown solid.

Workup

  1. customThe solvent was removed
  2. customthe product precipitated from diethyl ether

Sources & evidence

ORD record
ord-5c7d6d6cba174aa98bf1f687bc51a3ed
Source dataset
uspto-grants-2002_01
Patent number
US06337342B1

Reaction notes

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