反应详情

500 mg (2.04 mmol) of 2-allylamino-4-amino-6-nitroquinazoline was dissolved in 5 ml of DMF, and then 80 mg (2.33 mmol) of 70% sodium hydride and 280 mg (2.05 mmol) of 2-methylpropoxycarbonyl chloride were added thereto under ice cooling, followed by stirring for 3 hours. Water was added to the reaction solution, followed by extraction with ethyl acetate, successive washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 131 mg (19.1%) of the title compound.

1. extractionfollowed by extraction with ethyl acetate
2. washsuccessive washing with brine
3. dry with materialdrying over anhydrous sodium sulfate
4. distillationAfter the solvent was distilled off
5. customthe residue was purified by a silica gel column