Picolinic acid → Diethyl 2-(6-chloro-5-methylpyridin-3-yl)malonate

HRID 125081Notes

Reaction equation

HRID 125081 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:9])[c:5]([Cl:8])[n:6][cH:7]1.[C:10](=[O:11])([O-:12])[O-:13].[C:25]([CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])(=[O:32])[O:33][CH2:34][CH3:35].[Cs+:14].[Cs+:15].[Cu:36][I:37].[n:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[C:22]([OH:23])=[O:24]>>[c:2]1([CH:26]([C:25](=[O:32])[O:33][CH2:34][CH3:35])[C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:3][c:4]([CH3:9])[c:5]([Cl:8])[n:6][cH:7]1

Participants

7

Reactant 6

HCID 1018Picolinic acidHCID 7761Diethyl MalonateHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 2854345-Bromo-2-chloro-3-methylpyridine

Product 1

HCID 58447937Diethyl 2-(6-chloro-5-methylpyridin-3-yl)malonate

Sources & evidence

ORD record
ord-20bdddcccb1a4f199e6b92a674e1607e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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