反应详情

1,3-Dibromoisoquinoline (2.70 g), N-ethylpiperazine (1.16 g) and potassium carbonate (3.50 g) were reacted in DMF (30 ml) at 80° C. for 5 hr. The reaction solution was evaporated, and then partitioned between ethyl acetate and water. The resulting organic layer was washed with water, dried and evaporated. The resulting residue was purified by NH silica gel column chromatography (ethyl acetate/n-hexane system), to give the title compound (2.21 g) as a pale yellow oil.

1. customThe reaction solution was evaporated
2. custompartitioned between ethyl acetate and water
3. washThe resulting organic layer was washed with water
4. customdried
5. customevaporated
6. customThe resulting residue was purified by NH silica gel column chromatography (ethyl acetate/n-hexane system)