Hydrochloric Acid → HCID 18323657, compound

HRID 1251322Notes

Reaction equation

HRID 1251322 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]([CH2:21][CH2:22][CH2:23][N:24]2[CH2:29][CH:28]=[C:27]([C:30]3[C:38]4[C:33](=[CH:34][C:35]([F:39])=[CH:36][CH:37]=4)[NH:32][CH:31]=3)[CH2:26][CH2:25]2)[C:18](=[O:20])[CH3:19])[CH2:11][CH2:10]1.C([SiH](CC)CC)C.[ClH:47]>FC(F)(F)C(O)=O>[ClH:47].[ClH:47].[ClH:47].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][N:17]([CH2:21][CH2:22][CH2:23][N:24]2[CH2:29][CH2:28][CH:27]([C:30]3[C:38]4[C:33](=[CH:34][C:35]([F:39])=[CH:36][CH:37]=4)[NH:32][CH:31]=3)[CH2:26][CH2:25]2)[C:18](=[O:20])[CH3:19])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 12052TriethylsilaneHCID 18323644HCID 18323644, compound

Product 1

HCID 18323657HCID 18323657, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Following the same procedures reported in the EXAMPLE 4, the double bond reduction of the compound of EXAMPLE 8 (0.307 mmol) with triethylsilane (0.337 mmol) in trifluoroacetic acid followed by treatment with hydrochloric acid gave the title compound.

Sources & evidence

ORD record
ord-72fae30f20bc43c3bb9efc5e8bc2b580
Source dataset
uspto-grants-2002_01
Patent number
US06342498B1

Reaction notes

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