Acetone Cyanohydrin → HCID 10560421, compound

HRID 1251368Notes

Reaction equation

S([O-])([O-])(=O)=O.[Mg+2].[CH3:7][C:8]([N:10](C)C)=O.[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.[S:19]1[CH2:24][CH2:23]C(=O)[CH2:21][CH2:20]1.CC(C)(O)C#N>>[N:13]1([C:7]2([C:8]#[N:10])[CH2:23][CH2:24][S:19][CH2:20][CH2:21]2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

Reactant 5

HCID 6406Acetone Cyanohydrin

HCID 8082Piperidine

HCID 24083Sulfuric acid magnesium salt (1:1)

HCID 31374Dimethylacetamide

HCID 66173Tetrahydrothiopyran-4-one

Product 1

HCID 10560421HCID 10560421, compound

Conditions

Temperature: 45 °C

Procedure

Magnesium sulphate (9.3 g, 77.4 mmoles), DMA (2.25 g, 25.8 mmoles), piperidine (4.4 g, 51.6 mmoles), tetrahydro-4H-thiopyran-4-one (3 g, 25.8 mmoles) and acetone cyanhydrin (2.2 g, 25.8 mmoles) are introduced in succession into a 250 ml two-necked flask. The reaction medium is agitated for 48 hours at 45° C.

Sources & evidence

ORD record: ord-6d03aaa6c62443eaa0f43000c4f8de59
Source dataset: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06342511B1

Reaction notes

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