Acetone Cyanohydrin → HCID 18323946, compound

HRID 1251370Notes

Reaction equation

HRID 1251370 reaction equation
[O-]S([O-])(=O)=O.[Mg+2].[CH3:7][C:8]([N:10](C)C)=O.[OH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[S:20]1[CH2:25][CH2:24]C(=O)[CH2:22][CH2:21]1.CC(C)(O)C#N>>[OH:13][CH:14]1[CH2:19][CH2:18][N:17]([C:7]2([C:8]#[N:10])[CH2:24][CH2:25][S:20][CH2:21][CH2:22]2)[CH2:16][CH2:15]1

Participants

6

Reactant 5

HCID 6406Acetone CyanohydrinHCID 24083Sulfuric acid magnesium salt (1:1)HCID 31374DimethylacetamideHCID 66173Tetrahydrothiopyran-4-oneHCID 79341Piperidin-4-ol

Product 1

HCID 18323946HCID 18323946, compound

Procedure

It is prepared from MgSO4 (7.2 g, 60 mmoles), DMA (2.62 g, 30 mmoles), 4-hydroxy-piperidine (3.03 g, 20 mmoles), tetrahydro-4H-thiopyran-4-one (2.32 g, 20 mmoles) and acetone cyanhydrin (1.7 g, 20 mmoles). After treatment of the reaction, a white solid is obtained (4.7 g) which is crystallized from anhydrous ether. In this way, white crystals are obtained (3.6 g, 79%). M.p.=79-81° C.

Workup

  1. customAfter treatment of the reaction
  2. customa white solid is obtained (4.7 g) which
  3. customis crystallized from anhydrous ether
  4. customIn this way, white crystals are obtained (3.6 g, 79%)

Sources & evidence

ORD record
ord-eacb37ce01b34d108084f991eea0e370
Source dataset
uspto-grants-2002_01
Patent number
US06342511B1

Reaction notes

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