Trifluoroacetic acid → HCID 22838088, compound

HRID 1252636Notes

Reaction equation

HRID 1252636 reaction equation
[OH:1][C:2]1[C:3](=[O:43])[CH:4]=[C:5]([C:8]([NH:10][N:11]2[CH2:15][CH2:14][N:13]([C:16]([NH:18][NH:19][S:20]([NH:23][C:24]([N:26]3[CH2:29][C@H:28]([NH:30]C(=O)OCC4C=CC=CC=4)[C:27]3=[O:41])=[O:25])(=[O:22])=[O:21])=[O:17])[C:12]2=[O:42])=[O:9])[NH:6][CH:7]=1.C1(SC)C=CC=CC=1.FC(F)(F)C(O)=O>>[NH2:30][C@H:28]1[CH2:29][N:26]([C:24]([NH:23][S:20]([NH:19][NH:18][C:16]([N:13]2[CH2:14][CH2:15][N:11]([NH:10][C:8]([C:5]3[NH:6][CH:7]=[C:2]([OH:1])[C:3](=[O:43])[CH:4]=3)=[O:9])[C:12]2=[O:42])=[O:17])(=[O:22])=[O:21])=[O:25])[C:27]1=[O:41]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 86742173HCID 86742173, compound

Product 1

HCID 22838088HCID 22838088, compound

Procedure

0.5 g of (S)-[1-[[[[2-[[3-[[(1,4-dihydro-5-hydroxy-4-oxo-2-pyridinyl)carbonyl]amino]-2-oxo-1imidazolidinyl]carbonyl]hydrazino]sulfonyl]amino]carbonyl]-2-oxo-3-azetidinyl]carbamic acid, phenylmethyl ester was added to a mixture of 0.5 ml of thioanisole and 2 ml of trifluoroacetic acid. The mixture was stirred overnight at room temperature and evaporated in vacuo. The residue was triturated with ethyl acetate to provide the title compound in quantitative yield.

Workup

  1. customevaporated in vacuo
  2. customThe residue was triturated with ethyl acetate

Sources & evidence

ORD record
ord-c97c744b20184f98b1f152bd51e124ea
Source dataset
uspto-grants-1988_05
Patent number
US04743685

Reaction notes

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