Chloroacetamide → HCID 14638261, compound

HRID 1253187Notes

Reaction equation

HRID 1253187 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:17]3[O:18][CH2:19][C:20](=[O:22])[NH:21][C:16]=3[N:15]=[C:14]([CH3:23])[N:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:31][C:32]([NH2:34])=[O:33]>C(C(C)=O)C>[NH2:34][C:32]([CH2:31][N:21]1[C:20](=[O:22])[CH2:19][O:18][C:17]2[C:12]([N:9]3[CH2:10][CH2:11][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][CH2:8]3)=[N:13][C:14]([CH3:23])=[N:15][C:16]1=2)=[O:33]

Participants

5

Reactant 3

HCID 6580ChloroacetamideHCID 11430Potassium CarbonateHCID 14638217HCID 14638217, compound

Product 1

HCID 14638261HCID 14638261, compoundYield 57.5%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A suspension containing 0.96 g of 4-(4-ethoxycarbonyl-1-piperazinyl)-2-methyl-6,7-dihydro-8H-pyrimido[5,4-b][1,4]oxazin-7-one (Example 1), 25 ml of methyl ethyl ketone, 0.5 g of anhydrous potassium carbonate and 0.31 g of chloroacetamide is boiled under stirring for 8 hours, filtered as hot, washed with methyl ethyl ketone and this filtrate is set aside. The precipitate is washed with water, then with ether and dried to give 0.65 g of the product, m.p.: 225°-227° C.

Workup

  1. filtrationfiltered as hot,
  2. washwashed with methyl ethyl ketone
  3. washThe precipitate is washed with water
  4. dry with materialwith ether and dried

Sources & evidence

ORD record
ord-e4ecac289af044e994d594660009c581
Source dataset
uspto-grants-1988_05
Patent number
US04748175

Reaction notes

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