Triethylamine → HCID 70415956, compound

HRID 1253191Notes

Reaction equation

HRID 1253191 reaction equation
C([N:3](CC)CC)C.[N:8]1([CH2:14][CH2:15][CH2:16]N)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.Cl[C:19]1[C:24]2[O:25][CH2:26][C:27](=[O:29])[NH:28][C:23]=2[N:22]=[C:21]([CH3:30])[N:20]=1>C1C=CC=CC=1>[CH3:30][C:21]1[N:20]=[C:19]([CH2:16][CH2:15][CH2:14][N:8]2[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[C:24]2[O:25][CH:26]([NH2:3])[C:27](=[O:29])[NH:28][C:23]=2[N:22]=1

Participants

5

Reactant 3

HCID 8471Triethylamine2×HCID 61055N-(3-Aminopropyl)morpholineHCID 608089HCID 608089, compound

Product 1

HCID 70415956HCID 70415956, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 0.7 ml of triethylamine and 1.44 g of 3-(4-morpholinyl)-1-propylamine is added in the course of 8 hours to a mixture containing 2 g of 4-chloro-2-methyl-6,7-dihydro-8H-pyrimido[5,4-b][1,4]oxazin-7-one and 1.4 ml of triethylamine in 5 ml of abs. benzene while stirring and refluxing. Then the mixture is refluxed under stirring for 8 hours, evaporated, the residue is taken up with 16 ml of water, triturated, filtered and washed with water and ether to give 1.1 g (36%) of the aimed product, m.p.: 165°-168° C.

Workup

  1. additionis added in the course of 8 hours to a mixture
  2. temperaturerefluxing
  3. temperatureThen the mixture is refluxed
  4. customevaporated
  5. customtriturated
  6. filtrationfiltered
  7. washwashed with water and ether

Sources & evidence

ORD record
ord-375b106deb084656af85505bc825075c
Source dataset
uspto-grants-1988_05
Patent number
US04748175

Reaction notes

Loading…