Potassium Iodide → HCID 70408646, compound

HRID 1253336Notes

Reaction equation

HRID 1253336 reaction equation
[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Br[CH:24]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)[C:25]([O:27][CH2:28][CH3:29])=[O:26]>CN(C=O)C.O>[CH3:37][O:36][C:33]1[CH:32]=[CH:31][C:30]([CH:24]([O:14][C:10]2[CH:11]=[CH:12][CH:13]=[C:8]([CH:2]([OH:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH:9]=2)[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:35][CH:34]=1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 131740Ethyl bromo(4-methoxyphenyl)acetateHCID 117900843-(1-Hydroxyhexyl)phenol

Product 1

HCID 70408646HCID 70408646, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a stirred mixture of 10 g of 3-(α-hydroxyhexyl)phenol, 7.8 g of potassium carbonate, and 4 g of potassium iodide in 400 ml of DMF was added 13.2 g of Ethyl 2-bromo-2(4-methoxyphenyl)acetate and stirring was continuted at room temperature for 40 hours. The reaction mixture was then diluted with water, extracted with ethyl acetate, dried over magnesium sulfate and evaporated to dryness. The oily residue (8 g) was chromatographed by HPLC using EtOAc-hexane (1:4) as eluent to give pure product.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialdried over magnesium sulfate
  3. customevaporated to dryness
  4. customThe oily residue (8 g) was chromatographed by HPLC
  5. customto give pure product

Sources & evidence

ORD record
ord-30620477ce124735abda3ca13c84723e
Source dataset
uspto-grants-1988_05
Patent number
US04748272

Reaction notes

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