反应详情

温度

110 °C

A 250 ml flask was charged with 3-Aminopyridine (8 g, 85 mmol) and diethyl 2-(ethoxymethylene)malonate (18.5 g, 85.6 mmol). The mixture was heated to 110° C. for 30 min, and then cooled to ambient temperature to give diethyl [(E)-(pyridin-3-ylimino)methyl]malonate.

1. temperaturecooled to ambient temperature