huagongshe.com
HRID1253854

反应详情

EQUATION

反应方程式

HRID 1253854 的结构方程式

REACTANTS

反应物

3
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：CC(C)C[C@@H](C(=O)O)N(C)C(=O)OC(C)(C)C
HCID7010555

未命名化合物

结构：Nc1ccc2ccncc2c1
HCID14660277

Isoquinolin-7-amine

C9H8N2

PRODUCTS

生成物

1
结构：CC(C)C[C@@H](C(=O)Nc1ccc2ccncc2c1)N(C)C(=O)OC(C)(C)C
HCID57788111

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To (S)-2-(tert-butoxycarbonyl(methyl)amino)-4-methylpentanoic acid in DMF was added EDC, DMAP and isoquinolin-7-amine. This mixture was stirred for 4 hours and the reaction was washed with NaHCO3 (sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, Hexanes/EtOAc) gave pure (S)-tert-butyl 1-(isoquinolin-7-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate (E87).

WORKUP

后处理

  1. washthe reaction was washed with NaHCO3 (sat)
  2. extractionextracted with EtOAc
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. customevaporated