Chloroacetyl chloride → HCID 15984041, compound

HRID 1255981Notes

Reaction equation

HRID 1255981 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1OCCOCCF)[N:12]=[CH:11][N:10]=[C:9]2[NH:23][C:24]1[CH:29]=[C:28]([Cl:30])[C:27]([Cl:31])=[CH:26][C:25]=1[F:32])=[O:4].ClC1C(Cl)=CC(NC2C3C(=CC=C(N)C=3)N=C([O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH2:63][CH2:64][F:65])N=2)=C(F)C=1.CCN(C(C)C)C(C)C.ClCC(Cl)=O>C1COCC1>[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH2:63][CH2:64][F:65])[N:12]=[CH:11][N:10]=[C:9]2[NH:23][C:24]1[CH:29]=[C:28]([Cl:30])[C:27]([Cl:31])=[CH:26][C:25]=1[F:32])=[O:4]

Participants

6

Reactant 4

HCID 6577Chloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 24960475HCID 24960475, compoundHCID 86618846HCID 86618846, compound

Product 1

HCID 15984041HCID 15984041, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 1b was prepared as described hereinabove for Compound 1a, using Compound 38b (0.085 gram, 0.16 mmol), DIPEA (0.33 mmol, 57.8 μl) and chloroacetylchloride (0.33 mmol, 26.4 μ) in THF (11 ml), as starting materials, to give 0.025 gram (26% yield) of the product.

Sources & evidence

ORD record
ord-02f231d9598445cfbb9f9ce7c54cfe3c
Source dataset
uspto-grants-2013_06
Patent number
US08461166B2

Reaction notes

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