Methyl iodide → 1-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one O-Methyloxime

HRID 12561Notes

Reaction equation

HRID 12561 reaction equation
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19](=[N:22][OH:23])[CH2:20][CH3:21])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[CH3:26]I>C1COCC1>[CH3:26][O:23][N:22]=[C:19]([C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[C:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:11]=1)[CH2:20][CH3:21]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 1363323391-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one Oxime2×

Product 1

HCID 722584711-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one O-Methyloxime

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following General Procedure Q, 1-(5,6-diphenyl-pyridin-2-yl)-propan-1-one oxime (Compound 81, 30 mg, 0.1 mmol), NaH (4.8 mg, 0.20 mmol) and MeI (140 mg, 0.99 mmol) in THF were reacted to obtain the title compound as an oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d523504399db40809f5e980e4e1ea47f
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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