Lithium hydroxide, monohydrate → HCID 24887408, compound

HRID 1256586Notes

Reaction equation

HRID 1256586 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21]([O:23]CC)=[O:22])[C:9]=2[S:26][CH3:27])=[CH:4][CH:3]=1.O[Li:29].O>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21]([O-:23])=[O:22])[C:9]=2[S:26][CH3:27])=[CH:4][CH:3]=1.[Li+:29]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 24887407HCID 24887407, compound

Product 1

HCID 24887408HCID 24887408, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a magnetically stirred solution of ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylsulfanyl-1H-pyrazole-3-carboxylate (4.9 g, 11 mmol) in tetrahydrofuran (100 ml) was added LiOH.H2O (0.47 gram, 11 mmol) and the resulting mixture was reacted for 20 hours at 35° C. and subsequently concentrated in vacuo. The obtained crude lithium 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylsulfanyl-1H-pyrazole-3-carboxylate was used in the next step.

Workup

  1. customthe resulting mixture was reacted for 20 hours at 35° C.
  2. concentrationsubsequently concentrated in vacuo

Sources & evidence

ORD record
ord-b3248ecd291343f6875a841aeb5e2255
Source dataset
uspto-grants-2013_06
Patent number
US08461184B2

Reaction notes

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