反应详情

温度

60 °C

A suspension of N-[2-(4-chlorophenyl)ethyl]-4-hydroxy benzamide (605 mg) and 1-chloro-isoquinoline-4-carboxylic acid methyl ester (443 mg) and potassium carbonate (332 mg) in DMF (4 ml) was stirred at 60° C. for two hours. Ethyl acetate was added thereto, and the reaction solution was washed with water, and then washed with a saturated saline solution. The organic layer was dried over anhydrous magnesium sulfate, and then evaporated under reduced pressure to remove the solvent. The resulting crude product was purified by column chromatography (NH type silica gel, chloroform/n-hexane=50 to 80%) to give methyl 1-(4-{[2-(4-chlorophenyl)ethyl]carbamoyl}phenoxy)isoquinoline-4-carboxylate (782 mg) as a colorless solid.

1. washthe reaction solution was washed with water
2. washwashed with a saturated saline solution
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. customevaporated under reduced pressure
5. customto remove the solvent
6. customThe resulting crude product was purified by column chromatography (NH type silica gel, chloroform/n-hexane=50 to 80%)