反应详情

温度

60 °C

A solution of NaOH (0.327 g, 8.18 mmol) and 4-iodophenol (1.5 g, 6.82 mmol) in 7.5 ml of DMF and 3.5 ml of THF was stirred at room temperature for 15 minutes. Then bromohexanol (1.482 g, 8.18 mmol) was added and the reaction mixture was warmed at 60° C. When the reaction is over, water was added (15 ml) and the mixture was extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulphate and after filtration the solvent was removed at reduced pressure. The product was isolated by silica gel column chromatography using a mixture of ethyl acetate:dichloromethane 3:7 as eluant. A white solid was obtained (1.509 g, yield 69%).

1. additionwas added (15 ml)
2. extractionthe mixture was extracted with ethyl acetate
3. dry with materialThe organic phase was dried over anhydrous sodium sulphate
4. filtrationafter filtration the solvent
5. customwas removed at reduced pressure
6. customThe product was isolated by silica gel column chromatography
7. customA white solid was obtained (1.509 g, yield 69%)