Oxalyl chloride → HCID 58127969, compound

HRID 1257421Notes

Reaction equation

HRID 1257421 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH2:11][C:12]([OH:14])=O)[CH:10]=1)=[O:5])[CH3:2].C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[Cl:18][C:12](=[O:14])[CH2:11][N:9]1[CH:10]=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]=[N:8]1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 59557975[4-(ethoxycarbonyl)-1H-pyrazol-1-yl]acetic acid

Product 1

HCID 58127969HCID 58127969, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of the compound (2.0 g) obtained in Example 115b in dichloromethane (20 mL) was cooled in an ice bath, and oxalyl chloride (2.5 g) and N,N-dimethylformamide (2 drops) were added. The reaction mixture was stirred at room temperature overnight and the solvent was evaporated under reduced pressure to give the title compound.

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-8acc7315a6ef47b78335a24e36382fe9
Source dataset
uspto-grants-2013_06
Patent number
US08461348B2

Reaction notes

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