Methyl iodide → HCID 25145519, compound

HRID 1257863Notes

Reaction equation

HRID 1257863 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:7]=[N:8][C:9]3[N:10]([C:12]([C:15]4([C:18]5[CH:19]=[C:20]6[C:25](=[CH:26][CH:27]=5)[N:24]=[CH:23][CH:22]=[CH:21]6)[CH2:17][CH2:16]4)=[CH:13][N:14]=3)[CH:11]=2)[CH:3]=[N:2]1.[C:28](=O)([O-])[O-].[K+].[K+].CI>CN(C)C=O>[CH3:28][N:1]1[CH:5]=[C:4]([C:6]2[CH:7]=[N:8][C:9]3[N:10]([C:12]([C:15]4([C:18]5[CH:19]=[C:20]6[C:25](=[CH:26][CH:27]=5)[N:24]=[CH:23][CH:22]=[CH:21]6)[CH2:17][CH2:16]4)=[CH:13][N:14]=3)[CH:11]=2)[CH:3]=[N:2]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 67224931HCID 67224931, compound

Product 1

HCID 25145519HCID 25145519, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 6-{1-[6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline (6 mg, 0.017 mmol) in N,N-dimethylformamide (200 μL) was added potassium carbonate (4.0 mg, 0.029 mmol) and methyl iodide (3 μL, 0.048 mmol). After stirring at RT for 16 h, the reaction mixture was purified by RP-HPLC to afford the desired product. LCMS: (M+H)=367.0.

Workup

  1. customthe reaction mixture was purified by RP-HPLC

Sources & evidence

ORD record
ord-f5712c7e97b94db4a653f1bb3fcd131b
Source dataset
uspto-grants-2013_06
Patent number
US08461330B2

Reaction notes

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