Triphenylphosphine → HCID 68506593, compound

HRID 1258480Notes

Reaction equation

HRID 1258480 reaction equation
[N:1]([C@H:4]1[C@H:12]2[O:13][C@H:6]([C@@H:7]3[C@H:11]2[S:10](=[O:15])(=[O:14])[N:9]([C:16]2[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[C:18]([C:24]([F:27])([F:26])[F:25])[CH:17]=2)[CH2:8]3)[CH2:5]1)=[N+]=[N-].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>C1COCC1.O>[NH2:1][C@H:4]1[C@H:12]2[O:13][C@H:6]([C@@H:7]3[C@H:11]2[S:10](=[O:15])(=[O:14])[N:9]([C:16]2[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[C:18]([C:24]([F:25])([F:26])[F:27])[CH:17]=2)[CH2:8]3)[CH2:5]1

Participants

5

Reactant 2

HCID 11776TriphenylphosphineHCID 90931987HCID 90931987, compound

Product 1

HCID 68506593HCID 68506593, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

The mixture of Examples 24i and 24ii was dissolved in a mixed solvent of THF (3 mL) and H2O (0.25 mL). To the mixture, PPh3 (147 mg, 0.56 mmol) was added. The mixture was stirred at 70° C. for 2 h, and then cooled down. The reaction mixture was purified by SCX cartridge to give a mixture of Examples 25i and 25ii.

Workup

  1. temperaturecooled down
  2. customThe reaction mixture was purified by SCX cartridge

Sources & evidence

ORD record
ord-c3b94ad125fe402db4e220cd28124692
Source dataset
uspto-grants-2013_06
Patent number
US08466171B2

Reaction notes

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