Hydrochloric Acid → HCID 835236, compound

Temperature

0 °C

4-Fluoro-N-(3-nitro-phenyl)-benzamide (10.0 g, 36.2 mmol) (Example I5) was dissolved in isopropanol (150 ml) and tin chloride (24.7 g, 130.3 mmol) was added. The mixture was cooled to 0° C. and a solution of concentrated hydrochloric acid (20 ml) was added slowly. The reaction mixture was stirred at 80° C. for 2 hours. Then ⅓ of the total volume of isopropanol was evaporated. Water (200 ml) was added to the concentrated mixture and a solution of aqueous sodium hydroxide (4N) was added to adjust the pH to 7-8. The phases were separated and the aqueous phase was extracted three times with ethyl acetate (200 ml). The combined organic extracts were dried over sodium sulfate and concentrated. The residue was purified by column chromatography on silica gel (eluent: ethyl acetate) to give N-(3-amino-phenyl)-4-fluoro-benzamide (5 g, 60% yield). 1H-NMR (CDCl3, 400 MHz): 7.93 (m, 2H), 7.27 (t, 2H), 7.01 (m, 1H), 6.89 (t, 1H), 6.78 (d, 1H), 5.01 (s, 2H) ppm.

1. customThen ⅓ of the total volume of isopropanol was evaporated
2. additionWater (200 ml) was added to the concentrated mixture
3. additiona solution of aqueous sodium hydroxide (4N) was added
4. customThe phases were separated
5. extractionthe aqueous phase was extracted three times with ethyl acetate (200 ml)
6. dry with materialThe combined organic extracts were dried over sodium sulfate
7. concentrationconcentrated
8. customThe residue was purified by column chromatography on silica gel (eluent: ethyl acetate)

ORD record

ord-0243244690264851999b38f1f73ac2fe

Source dataset

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08466180B2