Potassium Carbonate → HCID 88532156, compound

HRID 1258693Notes

Reaction equation

HRID 1258693 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[C:9](Cl)=[CH:8][C:6]([NH2:7])=[C:5]([N+:11]([O-:13])=[O:12])[CH:4]=1.Cl.[F:17][C:18]([F:26])([F:25])[CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.C([O-])([O-])=O.[K+].[K+]>CN1C(=O)CCC1>[F:1][C:2]([F:15])([F:14])[C:3]1[C:9]([N:22]2[CH2:23][CH2:24][CH:19]([C:18]([F:26])([F:25])[F:17])[CH2:20][CH2:21]2)=[CH:8][C:6]([NH2:7])=[C:5]([N+:11]([O-:13])=[O:12])[CH:4]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27738135-Chloro-2-nitro-4-(trifluoromethyl)anilineHCID 162181604-(Trifluoromethyl)piperidine hydrochloride

Product 1

HCID 88532156HCID 88532156, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The sub-title compound was prepared from 4-trifluoromethyl-5-chloro-2-nitro-aniline (100 mg, 0.42 mmol), 4-trifluoromethyl-piperidine hydrochloride (394 mg, 2.1 mmol) and K2CO3 (600 mg, 4.4 mmol) in NMP (2 mL) in analogy to example 3, step (a).

Sources & evidence

ORD record
ord-532df4f6581e44258ac41db2445c898b
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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