Sodium hydride → HCID 86761883, compound

HRID 1260527Notes

Reaction equation

HRID 1260527 reaction equation
[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[N:9][CH:10]=1)([CH3:3])[CH3:2].CS(O[CH2:24][CH:25]([NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH3:26])(=O)=O.[H-].[Na+]>CN(C=O)C>[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:26][CH:25]([NH:27][C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:34])[CH3:33])[CH3:24])=[CH:16][CH:17]=2)=[N:9][CH:10]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 144271842-tert-Butoxycarbonylaminopropyl methanesulfonateHCID 67071691HCID 67071691, compound

Product 1

HCID 86761883HCID 86761883, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-(5-Isopropoxypyridin-2-yloxy)phenol (592 mg, 2.41 mmol) and 2-tert-butoxycarbonylaminopropyl methanesulfonate (734 mg, 2.89 mmol) were reacted with sodium hydride in DMF in analogy to example 2c. Yield: 414 mg (43%), M+H+: 403.19.

Sources & evidence

ORD record
ord-e154427bf5a8411dbb1a0061007a946e
Source dataset
uspto-grants-2013_06
Patent number
US08470841B2

Reaction notes

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