反应详情

温度

65 °C

2-Methylsulfanyl-7-pyridin-2-yl-pyrrolo[2,1-f][1,2,4]triazine (0.173 g, 0.714 mmol) was dissolved in Methanol (5.00 mL) and Sodium Tungstate Dihydrate (19.0 mg, 0.0576 mmol), Acetic acid (0.338 mL, 5.94 mmol) and 50% Hydrogen Peroxide (0.150 mL, 2.64 mmol) were added. The reaction mixture was then stirred and heated at 65° C. overnight. More 50% Hydrogen Peroxide (0.1 mL) was added and the reaction continued stirring. Once the reaction was complete, 5 mL of 10% Na2S2O3 and 2 mL 50% sat. NaHCO3 were added and the reaction was let cool to room temperature followed by refrigeration. The precipitate was then filtered and placed on the high vac to afford 2-Methanesulfonyl-7-pyridin-2-yl-pyrrolo[2,1-f][1,2,4]triazine.

1. stirringthe reaction continued stirring
2. temperaturethe reaction was let cool to room temperature
3. filtrationThe precipitate was then filtered