Triethylamine → HCID 12796234, compound

HRID 1262534Notes

Reaction equation

HRID 1262534 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=O)=[CH:7][C:6]=1[Cl:15])[CH:2]=[CH2:3].Cl.[CH2:17]([O:19][C:20](=[O:23])[CH2:21][NH2:22])[CH3:18].C(N(CC)CC)C.C1CCC(N=C=NC2CCCCC2)CC1>O1CCCC1.C(Cl)(Cl)Cl>[CH2:17]([O:19][C:20](=[O:23])[CH2:21][NH:22][C:12](=[O:14])[CH2:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:1][CH:2]=[CH2:3])=[C:6]([Cl:15])[CH:7]=1)[CH3:18]

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 30951AlclofenacHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 12796234HCID 12796234, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Procedure

4-Allyloxy-3-chloro-phenylacetic acid (4.3 g) was dissolved in dry tetrahydrofuran (20 ml). To the solution was added glycine ethyl ester hydrochloride (2.85 g) in dry chloroform (30 ml) containing dry triethylamine (2.8 ml). DCC (4.1 g) was added and the reaction mixture was stirred overnight at room temperature.

Sources & evidence

ORD record
ord-f5f8b8a4323f46f5a2edcb9764036443
Source dataset
uspto-grants-1984_06
Patent number
US04452783

Reaction notes

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