Hydrochloric Acid → HCID 11615198, compound

HRID 1262874Notes

Reaction equation

HRID 1262874 reaction equation
[F:1]/[CH:2]=[C:3](/[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)\[CH2:4][N:5]1C(=O)C2=CC=CC=C2C1=O.O.NN.Cl.O>C(O)C>[C:16]1(/[C:3](=[CH:2]/[F:1])/[CH2:4][NH2:5])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 13320105HCID 13320105, compound

Product 1

HCID 11615198HCID 11615198, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(Z)-1-Fluoro-2-phenyl-3-phthalimidopropene (0.25 g) is treated with hydrazine hydrate (50 mg) in ethanol (2 ml), and then concentrated hydrochloric acid (2 ml) and water (2 ml). Recrystallization of the resulting product (0.19 g) from ethanol/ether affords pure (Z)-2-phenyl-3-fluoroallylamine, as the hydrochloride: m.p. 145°;

Workup

  1. customRecrystallization of the resulting product (0.19 g) from ethanol/ether

Sources & evidence

ORD record
ord-5c253bfea547459f93205d6492117d5e
Source dataset
uspto-grants-1984_06
Patent number
US04454158

Reaction notes

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