Iodoethane → HCID 178477462, compound

HRID 1263241Notes

Reaction equation

HRID 1263241 reaction equation
[CH3:1][O:2][CH:3]([O:23][CH3:24])[CH2:4][NH:5][C:6]([NH:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=[S:7].[I:25][CH2:26][CH3:27].C(OCC)(=O)C.O(C(C)C)C(C)C>C(O)(=O)C>[IH:25].[CH3:24][O:23][CH:3]([O:2][CH3:1])[CH2:4][NH:5][C:6]([S:7][CH2:26][CH3:27])=[N:8][N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1

Participants

6

Reactant 4

HCID 6340IodoethaneHCID 7914Diisopropyl EtherHCID 8857Ethyl AcetateHCID 12952717HCID 12952717, compound

Product 1

HCID 178477462HCID 178477462, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 17.3 parts of N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]thiourea, 17 parts of iodoethane, 180 parts of ethyl acetate and 20 parts of acetic acid is stirred for 3 hours. Upon the addition of 2,2'-oxybispropane, the product is precipitated. It is filtered off and triturated in 4-methyl-2-pentanone. The product is filtered off and crystallized from 2-propanol, yielding 9 parts of ethyl N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]carbamimidothioate monohydroiodide.

Workup

  1. customthe product is precipitated
  2. filtrationIt is filtered off
  3. customtriturated in 4-methyl-2-pentanone
  4. filtrationThe product is filtered off
  5. customcrystallized from 2-propanol

Sources & evidence

ORD record
ord-a66a5917f3804ae28dd53bd617bd03fb
Source dataset
uspto-grants-1984_06
Patent number
US04456605

Reaction notes

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