反应详情

To 4-carbomethoxybenzaldehyde (79 mg, 0.48 mmol) and acetophenone (56 μL, 0.48 mmol) in anhydrous methanol (1.6 mL), was added neat sodium methoxide (26 mg, 0.48 mmol). The mixture was stirred at room temperature overnight then heated to reflux for 1 hour, cooled down to room temperature and added HCl 1N and EtOAc. The layers were separated and the organic layer dried over anhydrous MgSO4 and filtered. The solvent was evaporated under vacuum to afford a yellow solid, which was recrystallized from acetonitrile/water to give a pale yellow crystalline solid.

1. temperaturethen heated
2. temperatureto reflux for 1 hour
3. temperaturecooled down to room temperature
4. customThe layers were separated
5. dry with materialthe organic layer dried over anhydrous MgSO4
6. filtrationfiltered
7. customThe solvent was evaporated under vacuum
8. customto afford a yellow solid, which
9. customwas recrystallized from acetonitrile/water
10. customto give a pale yellow crystalline solid