Trifluoroacetic acid → HCID 72299639, compound

HRID 1264555Notes

Reaction equation

HRID 1264555 reaction equation
[CH3:1][NH:2][C:3](=[O:53])[CH:4]([N:12]1[C:18](=[O:19])[CH:17]([NH:20][C:21](=[O:48])[CH:22]([S:38]CC2C=CC(OC)=CC=2)[CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]3=[CH:33][CH:34]=[CH:35][CH:36]=[C:29]3[C:28]2=[O:37])[CH2:16][C:15]2[CH:49]=[CH:50][CH:51]=[CH:52][C:14]=2[CH2:13]1)[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>C([O-])(=O)C.[Hg+2].C([O-])(=O)C>[CH3:1][NH:2][C:3](=[O:53])[CH:4]([N:12]1[C:18](=[O:19])[CH:17]([NH:20][C:21](=[O:48])[CH:22]([SH:38])[CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:28](=[O:37])[C:29]3=[CH:36][CH:35]=[CH:34][CH:33]=[C:30]3[C:31]2=[O:32])[CH2:16][C:15]2[CH:49]=[CH:50][CH:51]=[CH:52][C:14]=2[CH2:13]1)[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 131723843HCID 131723843, compound

Product 1

HCID 72299639HCID 72299639, compound

Reagents, catalysts & solvents 1

HCID 15337Mercuric acetateCatalyst

Procedure

Prepare by the method of Example 3.3 using 2-(4-(2-(p-methoxybenzylthio)-6-phthalimidohexanoyl-amino)-3-oxo-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl)-3-phenyl-propionic acid, N-methyl amide, mercury (II) acetate, anisole, and trifluoroacetic acid to give the title compound.

Sources & evidence

ORD record
ord-66480be20d7b4ba78e70a93b93eab7cd
Source dataset
uspto-grants-2003_04
Patent number
US06544980B2

Reaction notes

Loading…