反应详情

3-(5-Hydroxymethyl-thiazol-4-yl)-benzoic acid methyl ester (1.25 g), dihydropyrane (0.84 mL) and p-toluenesulfonic acid hydrate (0.10 g) in AcOEt (12 mL) was stirred at 20° C. for 3 h. The solution was diluted AcOEt, washed with 5% NaHCO3 solution and with brine, dried and evaporated. The residual oil was purified by chromatography on silica gel using AcOEt/hexane (1:3) as eluent to give 3-[5-(tetrahydro-pyran-2-yloxymethyl)-thiazol-4-yl]-benzoic acid methyl ester (1.60 g) as a pale-yellow oil.

1. washwashed with 5% NaHCO3 solution and with brine
2. customdried
3. customevaporated
4. customThe residual oil was purified by chromatography on silica gel