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0 °C

To a solution of 4′-trifluoromethyl-biphenyl-2-carboxylic acid (4-piperazin-1-yl-phenyl)-amide (310 mg) in 1,2-dichloroethane (20 mL) was added 1H-pyrrole-2-carboxaldehyde (95 mg) and acetic acid (67 mg). The solution was cooled at 0° C. and sodium triacetoxy borohydride (317 mg) was added portionwise and the mixture was stirred at room temperature for 16 hours. The solution was then washed with a saturated solution of NaHCO3, with brine, dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by flash chromatography eluting with CH2Cl2/MeOH (95/5) and the solid obtained was recrystallized from EtOH to give the title compound (180 mg) as white crystals.

1. washThe solution was then washed with a saturated solution of NaHCO3, with brine
2. dry with materialdried over Na2SO4
3. filtrationfiltered
4. customevaporated under reduced pressure
5. customThe residue was purified by flash chromatography
6. washeluting with CH2Cl2/MeOH (95/5)
7. customthe solid obtained
8. customwas recrystallized from EtOH